A5175

A Phase IV, Prospective, Randomized, Open-Label Evaluation of the Efficacy of Once-Daily PI & Once-Daily Non-NRTI – Containing Therapy Combinations for Initial Treatment of HIV-1 Infected individuals from Resource – Limited Settings (PEARLS) Trial

Sponsors: US National Institute of Allergy and Infectious Diseases (NIAID)

Protocol Summary: A5175 was a phase IV, randomized, open-label, three-arm, antiviral efficacy trial designed to evaluate three antiretroviral (ARV) regimens for treatment-naïve HIV-infected participants: one regimen containing two nucleoside reverse transcriptase inhibitors (NRTIs) + a protease inhibitor (PI) and two regimens each containing two NRTIs + a non-nucleoside reverse transcriptase inhibitor (NNRTI).

Years: 2005 – 2009

Investigator: James Hakim, MBChB, FRCP

Location: Parirenyatwa CRS

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