HPTN 052

A Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy Plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Serodiscordant Couples

Division of AIDS, US National Institute of Allergy and Infectious Diseases (NIAD)
National Institutes of Health (NIH)

Protocol Summary:
HPTN 052 is a phase III, two-arm, randomized, controlled, multi-center study that aims to determine if antiretroviral therapy (ARV) can prevent sexual transmission of HIV-1 in HIV-1 serodiscordant couples. Couples were assigned to one of two study arms: 1) immediate initiation of ART in the HIV-infected partner upon enrollment, or 2) delayed initiation of ART in the HIV-infected partner until two consecutive CD4 cell counts were at or below 250 cells/mm3 or an AIDS-defining illness developed.

Years: 2007 – 2015

Investigator: James Hakim, MBChB, FRCP

Location: Parirenyatwa CRS

Publication: Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, et al. (2011) Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 365(6): 493-505.

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